HLA B27 Test: A Closer Look at Your Immune System
Chronic joint pain, lower back stiffness, or recurring eye inflammation can sometimes be more than just isolated symptoms. These signs may point toward an overactive immune system, and that’s where the HLA B27 test comes in.
This diagnostic test checks for the presence of a specific genetic marker often linked to autoimmune conditions. It plays an important role in supporting a diagnosis when clinical symptoms aren’t clearly defined. Doctors often recommend it to rule out or confirm certain inflammatory disorders.
Why Is the HLA B27 Test Done?
This test is not a routine one. It’s usually advised when someone shows symptoms suggestive of diseases like ankylosing spondylitis, reactive arthritis, or uveitis. These are autoimmune or autoinflammatory disorders where the body mistakenly attacks its own tissues, particularly joints, spine, or eyes.
The HLA B27 test helps doctors narrow down the possibilities, especially in the early stages when imaging results might not be conclusive. It supports early detection, which is key for effective treatment and disease management.
What Symptoms Might Prompt This Test?
- Frequent lower back pain that improves with activity
- Joint stiffness or swelling, especially in the knees or ankles
- Recurrent eye redness, pain, or vision changes (suggestive of uveitis)
- A history of skin or bowel inflammation with joint discomfort
If these signs persist without a clear cause, your doctor may suggest the HLA B27 test to investigate further.
The Testing Process
There’s nothing complicated about the procedure. A small sample of blood is collected from a vein, typically from your arm. No fasting or special preparation is required, and the process usually takes just a few minutes.
Once the sample is analyzed, the result is reported as either positive or negative.
Understanding the Results
A positive HLA B27 result means the gene was detected in your blood. While this doesn’t confirm a disease, it indicates a higher likelihood of developing related autoimmune conditions.
On the other hand, a negative result lowers that probability but doesn’t rule it out entirely—some patients with autoimmune symptoms can test negative yet still have the disease.
That’s why the HLA B27 test should always be interpreted in combination with physical findings, medical history, and other investigations.
Cost of HLA B27 Test in India
In India, the cost of this test typically ranges from ₹1500 to ₹3500 depending on the city, lab, and services included. For trustworthy and affordable testing, Redcliffe Labs offers doorstep sample collection, quick turnaround times, and certified lab reports—all at competitive prices.
Final Thoughts
The HLA B27 test serves as a valuable diagnostic clue for autoimmune and inflammatory conditions. If your symptoms persist without explanation, don’t ignore them. Early testing can lead to earlier diagnosis and better quality of life.
You can book this test easily through Redcliffe Labs—trusted by thousands for timely, accurate, and affordable diagnostics.
